//Create a byte array that will eventually hold our final PDF
Byte[] bytes;

//Boilerplate iTextSharp setup here
//Create a stream that we can write to, in this case a MemoryStream
using (var ms = new MemoryStream()) {

    //Create an iTextSharp Document which is an abstraction of a PDF but **NOT** a PDF
    using (var doc = new Document()) {

        //Create a writer that's bound to our PDF abstraction and our stream
        using (var writer = PdfWriter.GetInstance(doc, ms)) {

            //Open the document for writing
            doc.Open();

            //Our sample HTML and CSS
            var example_html = @"<p>This <em>is </em><span class=""headline"" style=""text-decoration: underline;"">some</span> <strong>sample <em> text</em></strong><span style=""color: red;"">!!!</span></p>";
            var example_css = @".headline{font-size:200%}";

            /**************************************************
             * Example #1                                     *
             *                                                *
             * Use the built-in HTMLWorker to parse the HTML. *
             * Only inline CSS is supported.                  *
             * ************************************************/

            //Create a new HTMLWorker bound to our document
            using (var htmlWorker = new iTextSharp.text.html.simpleparser.HTMLWorker(doc)) {

                //HTMLWorker doesn't read a string directly but instead needs a TextReader (which StringReader subclasses)
                using (var sr = new StringReader(example_html)) {

                    //Parse the HTML
                    htmlWorker.Parse(sr);
                }
            }

            /**************************************************
             * Example #2                                     *
             *                                                *
             * Use the XMLWorker to parse the HTML.           *
             * Only inline CSS and absolutely linked          *
             * CSS is supported                               *
             * ************************************************/

            //XMLWorker also reads from a TextReader and not directly from a string
            using (var srHtml = new StringReader(example_html)) {

                //Parse the HTML
                iTextSharp.tool.xml.XMLWorkerHelper.GetInstance().ParseXHtml(writer, doc, srHtml);
            }

            /**************************************************
             * Example #3                                     *
             *                                                *
             * Use the XMLWorker to parse HTML and CSS        *
             * ************************************************/

            //In order to read CSS as a string we need to switch to a different constructor
            //that takes Streams instead of TextReaders.
            //Below we convert the strings into UTF8 byte array and wrap those in MemoryStreams
            using (var msCss = new MemoryStream(System.Text.Encoding.UTF8.GetBytes(example_css))) {
                using (var msHtml = new MemoryStream(System.Text.Encoding.UTF8.GetBytes(example_html))) {

                    //Parse the HTML
                    iTextSharp.tool.xml.XMLWorkerHelper.GetInstance().ParseXHtml(writer, doc, msHtml, msCss);
                }
            }


            doc.Close();
        }
    }

    //After all of the PDF "stuff" above is done and closed but **before** we
    //close the MemoryStream, grab all of the active bytes from the stream
    bytes = ms.ToArray();
}

//Now we just need to do something with those bytes.
//Here I'm writing them to disk but if you were in ASP.Net you might Response.BinaryWrite() them.
//You could also write the bytes to a database in a varbinary() column (but please don't) or you
//could pass them to another function for further PDF processing.
var testFile = Path.Combine(Environment.GetFolderPath(Environment.SpecialFolder.Desktop), "test.pdf");
System.IO.File.WriteAllBytes(testFile, bytes);