prova con questo :
'create the mail message
Dim mail As New MailMessage()
'set the addresses
mail.From = New MailAddress("me@mycompany.com")
mail.To.Add("you@yourcompany.com")
'set the content
mail.Subject = "This is an email"
mail.Body = "this is a sample body"
'send the message
Dim smtp As New SmtpClient("127.0.0.1")
smtp.Send(mail)